But high-frequency sound pressure can also be applied to microscopic structures—cells, viruses, and the molecules in a broad range of liquids and gases. The team's specialty is devising ways of carefully controlling sound pressure to use it either as a probe for identifying the contents of closed containers or as a microscopic mover, capable of concentrating airborne or liquid-borne particles to facilitate their analysis.

Many of the team's inventions rely on the positive reinforcement of sound-pressure waves to generate larger-amplitude waves—the phenomenon of resonance or "standing waves." Church bells in a carillon exemplify this acoustic phenomenon. Differing in size and often in thickness, bells not only produce a characteristic frequency (pitch) when struck, but they continue to resonate with one or more frequencies thereafter. Each bell's unique characteristics as a sound conductor define the frequencies that reinforce one another, thus setting up standing waves, which we hear as a bell's lingering reverberation.

Because liquids differ in properties such as the speed at which they conduct sound and how much they absorb sound waves, a container's contents affect sound-wave transmission, which consequently exhibits peaks at certain frequencies. The contents thus "pick out" their own resonant frequencies. The resulting spectrum of standing waves superimposes two sound signatures—one for container's wall and one for its contents. This "resonance spectrum" is monitored by a sensitive detector, and mathematical relationships are used to extract properties such as liquid sound speed, sound absorption (attenuation), and density. When compared against a database of acoustic signatures, the properties derived from the resonance spectrum can identify a container's contents.

In addition, by improving on existing sound-projection technology using carrier waves, the team can introduce its resonance-probing sound waves into a container from distances of up to 15 feet. When containers may enclose highly toxic or inflammable substances, such standoff diagnosis is clearly desirable.

One of many acoustic techniques whose development was sponsored by the Department of Defense, acoustic interferometry also has medical applications. An example is diagnosing arthritis or osteoporosis by comparing the acoustic characteristics of diseased joints and bone with those of their healthy counterparts. Novel applications are likewise anticipated as sound projection techniques continue to improve. For example, using sound pressure to launch decontaminating vapors could help to sanitize buildings, a need illustrated by the massive post-9/11 effort required to decontaminate the U.S. Senate offices of anthrax.

A liquid acoustic concentrator uses resonant sound pressure to move particles suspended in fluids that are contained within the cavity of a cylindrical transducer (a cylinder of piezoelectric material that converts electrical signals to sound pressure). The cavity's resonance frequency changes as the particles are concentrated. An investigator can query the liquid inside the concentrator about its particle content by observing how the cavity's resonance changes as a function of time. For example, a friendly yogurt bacterium like acidophilus differs in size, shape, and other physical properties from a food-spoiler like salmonella or a lethal bioterrorist agent like anthrax, and so its influence on the liquid and how it concentrates under sound pressure will also differ. Friend can thus be distinguished from foe within a few seconds of examining a container suspected of bacterial contamination.

This technique builds on previous success in which acoustic methods were used to detect the presence of salmonella contamination in unbroken eggs. Nor are acoustic concentrators limited to threat reduction. Applied slightly differently, resonant sound pressure can become a concentrator of blood, gently separating cells (the suspended particles) from plasma (the liquid).

The team has also devised an aerosol acoustic concentrator capable of concentrating airborne contaminants fifty to a hundredfold. Inserting this simple, inexpensive device into the inlet of portable air monitors—such as those that would be used to screen a workplace for anthrax contamination—boosts contaminant-detection sensitivity by that same fifty to a hundredfold, making it less likely that potentially lethal contaminants will escape detection.

By sending an electromagnetic pulse into the liquid and measuring the capacitance of a circuit that includes container and contents, the sensor assesses the liquid's dielectric property—its ability to store charge and potentially conduct a current. As anyone knows who has been ordered out of a swimming pool during a thunderstorm, water is a good electrical conductor. Hydrocarbons, however, are not. If a passenger's response to a polite inquiry about a container's contents ("it's baby food," for example) did not match the sensor's response, you might justifiably pursue a more comprehensive search.

The team's contribution to safety, health, and security is evident in each of these envisioned sound solutions. And with prospects for combining many of its inventions into suites of progressively more useful tools, the sounds seem destined to grow only sweeter.